Yes. I usually begin by thinking about the space as a whole: the angle/s the wall will be seen from, who uses the space, and the “feeling” you want to bring to the space. The imagery we create, the use of color, dynamic form, and subject are designed to fit your specfic space and audience.
As an example, Los Gatos Meadows had an elegant building with an awkward elevator lobby that all entering guests and residents had to pass through. There was a door on the back wall that was for the parking staff only and made the space confusing. They wanted to “dress up” the space and make a the small, windowless, and “visually choppy” lobby into an inviting place to linger while guests waited for the elevator to the main floors. The artwork was specifically designed to resolve the inherent architectural awkwardness. Here is the solution we came up with: